This article is a list of characters from the Alien vs. Predator franchise spanning numerous comic books and video games, and two films: Alien vs. Predator (2004) and Aliens vs. Predator: Requiem (2007), bringing together the fictional storylines and creatures of the Alien and Predator science fiction franchises.
Lance Henriksen was the only previous actor from either the Alien or Predator films to appear in the crossover franchise. Henriksen had portrayed the android Bishop in Aliens (1986) and a man claiming to be the android's creator in Alien 3 (1992). He returned to the franchise for the film Alien vs. Predator (2004) to portray billionaire and self-taught engineer Charles Bishop Weyland, the original founder and CEO of Weyland Industries (also known as Weyland Corporation), and the video game Aliens vs. Predator (2010) to voice future Weyland-Yutani CEO Karl Bishop Weyland. The Predator film The Predator (2018) also connects the franchises, with Breanna Watkins cast as Aliens character Newt Jorden, and Françoise Yip reprising her Requiem role as Cullen Yutani.