Anna Manning Comfort, M.D. (née Manning; January 19, 1845 – January 12, 1931) was an American physician who specialized in the treatment of women's diseases. She was the first woman medical graduate to practice in the state of Connecticut.
Comfort was also an activist and vocal opponent of American imperialism. She was a leader in the women's suffrage movement, as well as a social reformer who defended the rights of Native Americans and African Americans. A member of Sorosis since 1878, Comfort was also a pioneer clubwoman.